05 October 2020

Haplo Group and you and disease!

Did you do your DNA yet.  You can learn your Haplogroup from it.

Here is a explanation of it from Wikipedia:


 Haplogroup

From Wikipedia, the free encyclopedia

...haplotype is a group of alleles in an organism that are inherited together from a single parent,[1][2] and a haplogroup (haploid from the Greekἁπλοῦςhaploûs, "onefold, simple" and English: Group) is a group of similar haplotypes that share a common ancestor with a single-nucleotide polymorphism mutation.[3][4] More specifically, a haplogroup is a combination of alleles at different chromosomal regions that are closely linked and that tend to be inherited together. As a haplogroup consists of similar haplotypes, it is usually possible to predict a haplogroup from haplotypes. Haplogroups pertain to a single line of descent. As such, membership of a haplogroup, by any individual, relies on a relatively small proportion of the genetic material possessed by that individual.


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Then did you know your Haplogroup can determine if you can get certain illnesses as explained here:  



From their : Human Molecular Genetics

::Population Genetics and Disease Susceptibility: Characterization of Central European Haplogroups By mtDNA Gene Mutations, Correlation with D Loop Variants and Association With Disease 
Sabine Hofmann, Michaela Jaksch, Reimar Bezold, Sabine Mertens, Simone Aholt, Armin Paprotta, Klaus-Dieter Gerbitz Author Notes::

Human Molecular Genetics, Volume 6, Issue 11, October 1997, Pages 1835–1846, https://doi.org/10.1093/hmg/6.11.1835
Published:
 
01 October 1997

Their Abstract as follows: 

Abstract

Mitochondrial (mt)DNA haplogroups in a German control group (n = 67) were characterized by screening mitochondrial coding regions encompassing most of the ND, tRNA and cyt b genes. We used a PCR-SSCP screening approach followed by direct sequencing of polymorphic mtDNA fragments. Five major mtDNA lineages, diverging in at least nine different haplogroups, could be defined by characteristic polymorphic sites in mitochondrial genes. Additional sequencing of two hypervariable segments (HVS-I and II) of the non-coding displacement (D) loop in all control subjects revealed that certain D loop variants were strongly correlated with lineages and haplogroups, while others represented hotspots occurring frequently in different haplogroups. The existence of identified lineages and haplogroups received support from data in the literature, obtained by use of different approaches. Subsequently, we investigated four disease groups for association with these haplogroups: (i) LHON patients (n = 55) carrying at least one of the primary/intermediate LHON mutations at nt 3460, 11778, 14484 and/or 15257; (ii) patients suffering from Wolfram or DIDMOAD syndrome(n = 8); (iii) MELAS patients (n = 9); (iv) a group of children, who died from ‘sudden infant death syndrome’ (SIDS) (n = 9). The distribution patterns among the haplogroups of the disease groups (LHON, DIDMOAD and SIDS) differed considerably from the control population. LHON and DIDMOAD were significantly under-represented in the most frequent German haplogroup DC, but were concentrated in a mtDNA lineage defined by polymorphisms at nt 4216+11251+16126. As this lineage diverged into two precisely defined haplogroups, LHON and DIDMOAD could be assigned to the two haplogroups separately. Strikingly, SIDS was often found in association with two rare German haplogroups. MELAS patients were equally distributed among German haplogroups and, moreover, did not reveal any accumulation of specific D loop variants. We conclude that certain European mtDNA haplogroups define a genetic susceptibility basis for various disorders.


As you see in the abstract their are very telling illnesses/disease that have all to do with your Haplogroup.  Amazing and sad as stated in the abstract with SIDS.

So can your Haplogroup also keep you from becoming ill from Pandemics?  I tried to find this out.  There are no current studies on it.  Who knows in a few short years someone may take an interest an we might learn a result.

So you did do your DNA!  Did you know there is a service that can provide you with many answers.  I uploaded my raw DNA in a service called Prometheas.  It can tell you what color eyes you should have.  I had to share with them that nope my eyes are not so yellow as they say.  

It can let you know if Parkensons disease in in there too.  But mine was negative.  Lucky me and my decendants.


Covid Pandemic and ETC...

 So your Ancestor created you before sub-coming to a Pandemic. 

That's great because here you are.  There are still babies being created and born here in Covid-19 times.   How many of them will remember the pandemic Covid-19 and pass the lessons learned to the New Generations?


   We can be sure most likely we will not be around.  Write in your journals.  Keep your story going.


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